Throughput and Yield Improvement for a Continuous Discrete-Product Manufacturing System

A seam-welded steel pipe manufacturing process has mainly four distinct major design and/or operational problems dealing with buffer inventory, cutting tools, pipe sizing and inspection-rework facility. The general objective of this research is to optimally solve these four important problems to improve the throughput and yield of the system at a minimum cost. The first problem of this research finds the optimal buffer capacity of steel strip coils to minimize the maintenance and downtime related costs. The total cost function for this coil feeding system is formulated as a constrained non-linear programming (NLP) problem which is solved with a search algorithm. The second problem aims at finding the optimal tool magazine reload timing, magazine size and the order quantity for the cutting tools. This tool magazine system is formulated as a mixed-integer NLP problem which is solved for minimizing the total cost. The third problem deals with different type of manufacturing defects. The profit function of this problem forms a binary integer NLP problem which involves multiple integrals with several exponential and discrete functions. An exhaustive search method is employed to find the optimum strategy for dealing with the defects and pipe sizing. The fourth problem pertains to the number of servers and floor space allocations for the off-line inspection-rework facility. The total cost function forms an integer NLP structure, which is minimized with a customized search algorithm. In order to judge the impact of the above-mentioned problems, an overall equipment effectiveness (OEE) measure, coined as monetary loss based regression (MLBR) method, is also developed as the fifth problem to assess the performance of the entire manufacturing system. Finally, a numerical simulation of the entire process is conducted to illustrate the applications of the optimum parameters setting and to evaluate the overall effectiveness of the simulated system. The successful improvement of the simulated system supports this research to be implemented in a real manufacturing setup. Different pathways shown here for improving the throughput and yield of industrial systems reflect not only to the improvement of methodologies and techniques but also to the advancement of new technology and national economy

Effect of Heat Treatments under High Isostatic Pressure on the Transport Critical Current Density at 4.2 K and 20 K in Doped and Undoped MgB2 Wires

Annealing undoped MgB2 wires under high isostatic pressure (HIP) increases transport critical current density (Jtc) by 10% at 4.2 K in range magnetic fields from 4 T to 12 T and significantly increases Jtc by 25% in range magnetic fields from 2 T to 4 T and does not increase Jtc above 4 T at 20 K. Further research shows that a large amount of 10% SiC admixture and thermal treatment under a high isostatic pressure of 1 GPa significantly increases the Jtc by 40% at 4.2 K in magnetic fields above 6 T and reduces Jtc by one order at 20 K in MgB2 wires. Additionally, our research showed that heat treatment under high isostatic pressure is more evident in wires with smaller diameters, as it greatly increases the density of MgB2 material and the number of connections between grains compared to MgB2 wires with larger diameters, but only during the Mg solid-state reaction. In addition, our study indicates that smaller wire diameters and high isostatic pressure do not lead to a higher density of MgB2 material and more connections between grains during the liquid-state Mg reaction

Participatory and Institutional Approaches to Agricultural Climate Services: A South and Southeast Asia Regional Technical & Learning Exchange

In order to share experience and boost capacity in agricultural climate services, a three-day workshop titled ‘Participatory and Institutional Approaches to Agricultural Climate Services Development: A South and South East Asia Regional Technical and Learning exchange” was held between September 17-19, 2017, in Dhaka, Bangladesh, with more than 50 leaders in agricultural climate services from 11 countries attending. The workshop was sponsored by the U.S. Agency for International Development (USAID) behalf of the Climate Services for Resilient Development (CSRD). The workshop was organized by the International Maize and Wheat Improvement Center (CIMMYT) alongside the SERVIR and Climate Services Support Activity and CSRD South Asian partners

Evaluation of a solid nitrogen impregnated MgB2 racetrack coil

To develop powerful wind turbine generators using superconducting technology, high-performance superconducting racetrack coils are essential. Herein, we report an evaluation of a multifilamentary magnesium diboride (MgB2) conductor-based racetrack coil cooled and impregnated simultaneously by solid nitrogen (SN2). The coil was wound on a copper former with 13 mm winding width, an inner diameter of 124 mm at the curvature, and 130 mm length of the straight section. An in situ processed S-glass-insulated 36-filament MgB2 wire was wound on the former in two layers with 19.5 turns, and heat treated via the wind and react method without any epoxy resin. The coil was evaluated for critical temperature and transport critical current in the SN2 environment at different temperatures up to 31.3 K in self-field. The coil was able to carry 200 A transport current at 28.8 K in self-field. During coil charging and operation, SN2 effectively acted as an impregnation material. The test results demonstrate the viability to use MgB2 racetrack coil potentially with SN2 impregnation in advanced rotating machine applications

Bioelectromagnetics research within an Australian context: the Australian centre for electromagnetic bioeffects research (ACEBR)

Mobile phone subscriptions continue to increase across the world, with the electromagnetic fields (EMF) emitted by these devices, as well as by related technologies such as Wi-Fi and smart meters, now ubiquitous. This increase in use and consequent exposure to mobile communication (MC)-related EMF has led to concern about possible health effects that could arise from this exposure. Although much research has been conducted since the introduction of these technologies, uncertainty about the impact on health remains. The Australian Centre for Electromagnetic Bioeffects Research (ACEBR) is a National Health and Medical Research Council Centre of Research Excellence that is undertaking research addressing the most important aspects of the MC-EMF health debate, with a strong focus on mechanisms, neurodegenerative diseases, cancer, and exposure dosimetry. This research takes as its starting point the current scientific status quo, but also addresses the adequacy of the evidence for the status quo. Risk communication research complements the above, and aims to ensure that whatever is found, it is communicated effectively and appropriately. This paper provides a summary of this ACEBR research (both completed and ongoing), and discusses the rationale for conducting it in light of the prevailing science.Sarah P. Loughran ... Jim Manavis ... Robert Vink ... et al

Graphene-Oxide-Loaded Superparamagnetic Iron Oxide Nanoparticles for Ultrasensitive Electrocatalytic Detection of MicroRNA

We report the electrocatalytic activity of a new class of superparamagnetic nanoparticles, graphene-oxide-loaded iron oxide (GO/IO hybrid material), towards the reduction of ruthenium hexaammine(III) chloride (Ru(NH3)6]3+, RuHex). Leveraging the electrocatalytic activity of the GO/IO hybrid material and the signal enhancement capacity of [Ru(NH3)6]3+/[Fe(CN)6]3 in an electrocatalytic cycle, an ultrasensitive and specific electrochemical sensor was developed for the detection of cancerrelated microRNA (miRNA). Using the direct affinity interaction between RNA and graphene oxide, magnetically isolated and purified target miRNA were directly adsorbed onto a screenprinted electrode modified with the GO/IO hybrid material. The detection was enabled by chronocoulometric (CC) readout of charge-compensating [Ru(NH3)6]3+ followed by an enhancement in CC charge display through the Ru(NH3)6]3+ /[Fe(CN)6]3 system. We demonstrate an excellent limit of detection of 1.0 fM by accurately detecting miR-21 in synthetic samples and showcase its clinical utility in ovarian cancer cell lines with high sensitivity (ten cells) and good reproducibility (%RSD= \u3c5%, for n=3)

Quantification of gene-specific DNA methylation in oesophageal cancer via electrochemistry

Development of simple and inexpensive method for the analysis of gene-specific DNA methylation is important for the diagnosis and prognosis of patients with cancer. Herein, we report a relatively simple and inexpensive electrochemical method for the sensitive and selective detection of gene-specific DNA methylation in oesophageal cancer. The underlying principle of the method relies on the affinity interaction between DNA bases and unmodified gold electrode. Since the affinity trend of DNA bases towards the gold surface follows as adenine (A) > cytosine (C) > guanine (G)> thymine (T), a relatively larger amount of bisulfite-treated adenine-enriched unmethylated DNA adsorbs on the screen-printed gold electrodes (SPE-Au) in comparison to the guanine-enriched methylated sample. The methylation levels were (i.e., different level of surface attached DNA molecules due to the base dependent differential adsorption pattern) quantified by measuring saturated amount of charge-compensating [Ru(NH ) ] molecules in the surface-attached DNAs by chronocoulometry as redox charge of the [Ru(NH ) ] molecules quantitatively reflects the amount of the adsorbed DNA confined at the electrode surface. The assay could successfully distinguish methylated and unmethylated DNA sequences at single CpG resolution and as low as 10% differences in DNA methylation. In addition, the assay showed fairly good reproducibility (% RSD

AC loss and contact resistance of different CICC cable patterns: Experiments and numerical modeling

© 2020 The Author(s) For upcoming nuclear fusion energy reactors, like the China Fusion Engineering Test Reactor (CFETR) and EU-DEMO, the superconducting Cable-In-Conduit Conductors (CICC) are in the design phase, and the operating conditions like electromagnetic forces can be higher than in previous devices like ITER. The prototype conductors for the Central Solenoid (CS) coils in the CFETR, for example, are designed to produce a peak field of 19.9 T and are expected to be made of high current density Nb3Sn strands. Investigations are also ongoing on the application of bismuth strontium calcium copper oxide (BSCCO) and MgB2 strands for CICCs in fusion reactors. The latter material, MgB2, could be applied for superconductors subjected to lower magnetic fields, such as Poloidal Field coils, Correction Coils, and Feeders. The performance of all these strands is sensitive to strain, and the mechanical strength of the brittle filaments is relatively weak. This requires a thorough analysis of the cable pattern in terms of the mechanical support of the strands along their length in combination with the minimization of the interstrand coupling currents and strand indentation. As an initial step to finding the most appropriate cable pattern for CICCs, three prototype CICCs made of ITER type Nb3Sn strands with significantly different cable twist patterns are tested experimentally for AC coupling loss, interstrand contact resistance, and strand indentation. The three cabling patterns referred to as the Twente, CWS (copper wound superconducting strand), and CFETR-CSMC (CFETR Central Solenoid Model Coil) design. The numerical code JackPot ACDC developed at the University of Twente is used to analyze the interstrand coupling loss and contact resistance. The new ASIPP (Institute of Plasma Physics, Chinese Academy of Sciences) triplet modified CWS design is aimed at reducing strand pinching during cabling, which causes degradation of transport properties during compaction and cyclic loading. The Twente design has the same objective but also aims at reducing the coupling loss while maximizing the mechanical lateral support for the strands by making the twist pitch ratio of the sequential cabling stages close to one. The CFETR-CSMC, taken as a reference for comparison, has cable a pattern mostly similar to the ITER CS cable design

Gold-loaded nanoporous ferric oxide nanocubes for electrocatalytic detection of microRNA at attomolar level

A crucial issue in microRNA (miRNA) detection is the lack of sensitive method capable of detecting the low levels of miRNA in RNA samples. Herein, we present a sensitive and specific method for the electrocatalytic detection of miR-107 using gold-loaded nanoporous superparamagnetic iron oxide nanocubes (Au-NPFe 2 O 3 NC). The target miRNA was directly adsorbed onto the gold surfaces of Au-NPFe 2 O 3 NC via gold-RNA affinity interaction. The electrocatalytic activity of Au-NPFe 2 O 3 NC was then used for the reduction of ruthenium hexaammine(III) chloride (RuHex, [Ru(NH 3 ) 6 ] 3+ ) bound with target miRNA. The catalytic signal was further amplified by using the ferri/ferrocyanide [Fe(CN) 6 ] 3-/4- system. These multiple signal enhancement steps enable our assay to achieve the detection limit of 100 aM which is several orders of magnitudes better than most of the conventional miRNA sensors. The method was also successfully applied to detect miR-107 from cancer cell lines and a panel of tissue samples derived from patients with oesophageal squamous cell carcinoma with excellent reproducibility (% RSD = \u3c 5%, for n = 3) and high specificity. The analytical accuracy of the method was validated with a standard RT-qPCR method. We believe that our method has the high translational potential for screening miRNAs in clinical samples

Biological Functions and Current Advances in Isolation and Detection Strategies for Exosome Nanovesicles

Exosomes are nanoscale (≈30-150 nm) extracellular vesicles of endocytic origin that are shed by most types of cells and circulate in bodily fluids. Exosomes carry a specific composition of proteins, lipids, RNA, and DNA and can work as cargo to transfer this information to recipient cells. Recent studies on exosomes have shown that they play an important role in various biological processes, such as intercellular signaling, coagulation, inflammation, and cellular homeostasis. These functional roles are attributed to their ability to transfer RNA, proteins, enzymes, and lipids, thereby affecting the physiological and pathological conditions in various diseases, including cancer and neurodegenerative, infectious, and autoimmune diseases (e.g., cancer initiation, progression, and metastasis). Due to these unique characteristics, exosomes are considered promising biomarkers for the diagnosis and prognosis of various diseases via noninvasive or minimally invasive procedures. Over the last decade, a plethora of methodologies have been developed for analyzing disease-specific exosomes using optical and nonoptical tools. Here, the major biological functions, significance, and potential role of exosomes as biomarkers and therapeutics are discussed. Furthermore, an overview of the most commonly used techniques for exosome analysis, highlighting the major technical challenges and limitations of existing techniques, is presented